GsAF-II 

Blocker of Na_v1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7

鈉離子通道Na_v1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7阻斷劑

GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider.  peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Na_v1.1, Na_v1.2, Na_v1.3, Na_v1.4, Na_v1.6 and Na_v1.7 with IC₅₀ values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC₅₀ value of 4.7 µM.

技術資料

氨基酸序列：

Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Glu-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Leu-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Ile-Glu-Trp-OH 

二硫鍵：Cys²-Cys¹⁶, Cys⁹-Cys²¹, and Cys¹⁵-Cys²⁵

長度 (aa)：31 

分子式：C₁₇₆H₂₆₁N₄₇O₄₅S₇ 

分子量：  3979.78 Da 

外觀：White lyophilized solid 

可溶性：aqueous buffer 

CAS 號：not available 

來源：Synthetic 

純度：> 98%

產品信息