GsAF-I

Blocker of Na_v1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7

鈉離子通道Na_v1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7阻斷劑

GsAF-I (also termed β-theraphotoxin-Gr1b, GsAF-1) was originally isolated from the venom of Grammostola rosea spider. peptide toxin is reported to block the following voltage-gated sodium channel isoforms: Na_v1.1, Na_v1.2, Na_v1.3,Na_v1.4, Na_v1.6 and Na_v1.7 with respective IC₅₀ values of  0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC₅₀ value of 4.8 µM.

技術(shù)資料

氨基酸序列：

Tyr-Cys²-Gln-Lys-Trp-Leu-Trp-Thr-Cys⁹-Asp-Ser-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Asp-Met-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Arg-Leu-NH₂ 

二硫鍵：Cys²-Cys¹⁶, Cys⁹-Cys²¹, and Cys¹⁵-Cys²⁵ 

長度 (aa)： 29

分子式：C₁₆₀H₂₄₅N₄₇O₄₁S₇ 

分子量： 3707.48 Da

外觀： White lyophilized solid

可溶性：aqueous buffer

CAS 號：not available

來源： Synthetic

純度：> 98%

產(chǎn)品信息