Recombinant human CBL-B (Cbl proto-oncogene B) encompassing amino acids 39-426 (contains the SH2-like domain). This construct contains a His-tag (6xHis) followed by an Avi-Tag™, linked to the N-terminal end of the protein. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified.