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AAV-6 Anti-CD19 CAR (CD19 ScFv-CD8-
Anti–5–mC monoclonal antibody 33D3
The AAV-6 Anti-CD19 CAR (CD19 ScFv-CD8-4-1BB-CD3ζ) is an AAV 6 encoding the ScFv portion of anti-CD19 (clone FMC63) linked to the 2nd generation CAR (Chimeric Antigen Receptor) containing the CD8 hinge, 4-1BB and CD3ζ signaling domains, under the control of a EF1α promoter (Figure 1).
Figure 1. Schematic representation of AAV-6 Anti-CD19 CAR (CD19 ScFv-CD8-4-1BB-CD3ζ). The diagram indicates the components of the anti-CD19 CAR (ScFv-CD8-4-1BB-CD3ζ).
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