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CCR6 antagonist 1

CAS No. : 588674-64-0

產(chǎn)品活性：CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

研究領(lǐng)域：GPCR/G Protein  |  Immunology/Inflammation

作用靶點：CCR

In Vitro: CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4⁺ T cell migration.
CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively.

In Vivo: CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice.
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice.

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