目錄:MedChemExpress LLC>>生化試劑>> Bedinvetmab | MCE
CAS | 2171034-69-6 | 供貨周期 | 現(xiàn)貨 |
---|---|---|---|
規(guī)格 | 5 mg | 貨號 | HY-P99297 |
應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 2171034-69-6
產(chǎn)品活性:Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.
研究領(lǐng)域:Neuronal Signaling | Protein Tyrosine Kinase/RTK
作用靶點(diǎn):Trk Receptor
In Vivo: Bedinvetmab (0.5-1 mg/kg; s.c. for 28 d) alleviates the pain associated with canine osteoarthritis.
Bedinvetmab (1 mg/kg; s.c. monthly; 3× and 10× dose multiples) is well tolerated in normal laboratory Beagle dogs for 6 months and with 2 weeks' concurrent NSAID administration.
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