ZnDPA-Cy7和ZnDPA-FITC凋亡靶向探針(熒光細(xì)胞凋亡檢測(cè))
西安凱新生物科技有限公司新推出2款用于細(xì)胞凋亡熒光檢測(cè)產(chǎn)品ZnDPA-Cy7和ZnDPA-FITC,如需購(gòu)買(mǎi)請(qǐng)聯(lián)系我公司。
供應(yīng)商:西安凱新生物科技有限公司
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產(chǎn)品簡(jiǎn)介:
利用ZnDPA與磷脂酰絲氨酸的高度親和力,通過(guò)凋亡細(xì)胞外翻的磷脂酰絲氨酸特異性結(jié)合(或者細(xì)菌表面的磷脂酰絲氨酸)達(dá)到檢測(cè)凋亡細(xì)胞或者細(xì)菌的目的。
ZnDPA-Cy7產(chǎn)品結(jié)構(gòu)式:
ZnDPA-FITC產(chǎn)品結(jié)構(gòu)式:
參考文獻(xiàn):
1. Hanshaw RG, Lakshmi C, Lambert TN,Johnson JR and and Smith BD. Fluorescent detection of apoptotic cells by usingzinc coordination complexes with a selective affinity for membrane surfacesenriched with phosphatidylserine. ChemBioChem 2005, 12, 2214-2220.
2. Hanshaw RG and Smith BD. New reagentsfor phosphatidylserine recognition and detection of apoptosis. Bioorg. &Med. Chem. 2005, 13, 5035-5042.
3. Leevy, W. M.; Gammon, S. T.; Jiang, H.;Johnson, J. R.; Maxwell, D. J.; Marquez, M.; Piwinica-Worms, D.; Smith, B. D.Optical imaging of bacterial infection in living mice using a fluorescentnearinfrared molecular probe. J. Am. Chem. Soc. 2006, 128, 16476-16477.
4. Leevy, W. M.; Gammon, S. T.; Johnson, J.R.; Lampkins, A. J.; Jiang, H.; Marquez, M.; Piwinica-Worms, D.; Smith, B. D.Noninvasive optical imaging of staphylococcus aureus bacterial infection inliving mice using a bis-dipicolylamine-zinc (II) affinity group conjugated to anear-infrared fluorophore. Bioconjugate Chem. 2008, 19, 686-692.
產(chǎn)品應(yīng)用:
1、可以代替Annexin V-FITC通過(guò)激光共聚焦和流式細(xì)胞儀實(shí)現(xiàn)凋亡細(xì)胞的檢測(cè);
2、可以實(shí)現(xiàn)細(xì)胞/活體/組織對(duì)細(xì)菌的檢測(cè);
3、可以實(shí)現(xiàn)細(xì)胞/活體/組織對(duì)凋亡細(xì)胞的染色。