腫瘤壞死因子α誘導蛋白9/前列腺六跨膜上皮抗原4抗體

英文名稱 STEAP4
中文名稱 腫瘤壞死因子α誘導蛋白9/前列腺六跨膜上皮抗原4抗體
別    名 alpha-induced protein 9; Metalloreductase STEAP4; six transmembrane prostate protein 2; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; STAMP 2; STAMP2; STEA4_HUMAN; STEAP 4; STEAP4; TIARP; TNFAIP 9; TNFAIP9; Tumor necrosis factor; tumor necrosis factor, alpha-induced protein 9; tumor necrosis-alpha-induced adipose-related protein.
  
說 明 書 0.2ml  
研究領域 腫瘤  免疫學  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human STEAP4 (85-130aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.

Subunit:
Interacts with and phosphorylates PTK2/FAK1.

Subcellular Location:
Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.

Tissue Specificity:
Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

Similarity:xy-11893R    NELF轉錄延伸因子NELF抗體
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xy-11895R    NELL2蛋白激酶C結合蛋白NELL2抗體
xy-11896R    NETO2腦特異性跨膜蛋白抗體
xy-11898R    NFIA核因子1A抗體
xy-11901R    NHLH1環一螺旋蛋白1抗體
xy-11902R    NME4腫瘤轉移抑制基因H4抗體
xy-11903R    神經元衍生孤兒受體1抗體
xy-10065R    Netrin 4軸突生長誘向因子4抗體
xy-10029R    Nectin 4脊髓灰質炎病毒受體相關蛋白4抗體
xy-10037R    NFKB p52細胞核因子/k基因結合核因子 p52/p100抗體
xy-11734R    NDUFS7線粒體復合物NDUFS7蛋白抗體
xy-11736R    NPC2尼曼匹克C2前體蛋白抗體
xy-11738R    Nmnat1煙酰胺腺嘌呤二核苷酸酶1抗體
xy-10197R    nNOS 一氧化氮合成酶-1抗體（神經型）
xy-12314R    NKX6.1轉錄因子相關蛋白NKX6.1抗體
xy-12345R    NCKAP1L造血蛋白1抗體
xy-10075R    Nidogen2骨巢蛋白抗體
xy-4028R    NUP54NUP54抗體
xy-3695R    NTF97親核素β1抗體
xy-7124R    NMDA epsilon 1谷氨酸受體NMDAζ1抗體
xy-8483R    NMDA epsilon 2谷氨酸受體NMDAζ2抗體
xy-3692R    Neurogenin 2神經元素2抗體
xy-3688R    NDRG3抑癌基因NDRG3抗體
xy-3682R    有絲分裂氧化酶1抗體
xy-3683R    NADPH oxidase 3NADPH oxidase 3抗體
xy-3684R    NADPH oxidase 4NADPH氧化酶NOX家族的成員4抗體
xy-7714R    CDCA1細胞分裂周期相關蛋白1抗體
xy-2680R    NFAM1NFAM1抗體
xy-11897R    NEURL環指蛋白67抗體
xy-6043R    NBL1神經母細胞瘤抑瘤蛋白1抗體
xy-3886R    NCF1嗜中性粒細胞胞漿因子1抗體
Belongs to the STEAP family.

Database links:
UniProtKB/Swiss-Prot: Q687X5.1