絲氨酸蛋白酶抑制劑B1抗體

英文名稱 SERPINB1
中文名稱 絲氨酸蛋白酶抑制劑B1抗體
別    名 Anti elastase; EI; ELANH2; ILEU_HUMAN; LEI; Leukocyte elastase inhibitor; M/NEI; MNEI; Monocyte/neutrophil elastase inhibitor; Peptidase inhibitor 2; Pi-2; PI2; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1; Serpin B1; Serpin peptidase inhibitor clade B (ovalbumin) member 1; serpinb1.
 
說 明 書 0.1ml  0.2ml  
研究領域 心血管  細胞生物  免疫學  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SERPINB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The monocyte/neutrophil elastase inhibitor gene, SERPINB1, belongs to the Ov-serpin family (ovalbumin-related serpins). Human SerpinB1, also designated monocyte/neutrophil elastase inhibitor (M/NEI) or leukocyte elastase inhibitor (LEI), is a cytoplasmic protein which acts as a fast-acting stoichiometric proteinase inhibitor that regulates the activity of neutrophil elastase (NE), cathepsin-G and proteinase-3. There are four homologous genes in mouse designated SerpinB1a, SerpinB1b, SerpinB1c and the pseudogene, Serpinb1-ps1. The three protein-coding genes share significant sequence identity, however SerpinB1a (also designated EIA) has been characterized as the functional ortholog of human SerpinB1.

Function:
Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.xy-9167R    RNF86環(huán)指蛋白86
xy-9168R    RING2環(huán)指蛋白2抗體
xy-9171R    RNF44環(huán)指蛋白44抗體
xy-9170R    RNF40環(huán)指蛋白40抗體
xy-9173R    RNF8環(huán)指蛋白8抗體
xy-6088R    RASAL1RAS蛋白樣激活劑1抗體
xy-2939R    RASSF2Ras相關結構域蛋白質(zhì)2抗體
xy-6093R    RIL抑癌基因PDLIM4抗體
xy-6094R    RIN1RAS抑制蛋白1抗體
xy-6101R    RUNX1T1周期素D相關蛋白抗體
xy-6095R    RND3Rho家族GTP酶3抗體
xy-6096R    RNF139環(huán)指蛋白139抗體
xy-6098R    Rho GTPase activating protein 29Rho GTP酶激活蛋白29抗體
xy-6097R    RSRC2食道癌抑制生長蛋白抗體
xy-6089R    RASSF8RAS家族關聯(lián)結構域蛋白8抗體
xy-4282R    Ran雄激素受體相關蛋白24抗體
xy-6501R    Rab25癌基因RAS相關蛋白Rab25抗體
xy-6219R    RXR beta核受體RXRβ抗體
xy-6218R    RAR gamma維甲酸受體γ抗體
xy-4630R    phospho-ROCK1(Thr455+Ser456)磷酸化Rho相關蛋白激酶1抗體
xy-6130R    RbAp48視網(wǎng)膜母細胞瘤結合蛋白P48抗體
xy-11358R    RIMBP2神經(jīng)元突觸膜結合蛋白2抗體
xy-11359R    RIMS3神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白3抗體
xy-11360R    RIMS4神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白4抗體
xy-11369R    SynGAP認知缺陷突觸相關蛋白SynGAP抗體
xy-11472R    RSPH4AKartagener綜合征相關蛋白RSHL3抗體
xy-11473R    RGMA反義導向分子RGMA抗體
xy-11474R    Repulsive Guidance Molecule B反義導向分子RGMB抗體
xy-11475R    RGMC/Repulsive Guidance Molecule C反義導向分子RGMC抗體
xy-11476R    Robo3軸突導向受體蛋白3抗體
xy-6916R    RABX5G蛋白相關RABX5抗體
xy-9226R    RNF157環(huán)指蛋白157抗體
xy-7518R    Ribonuclease Inhibitor核糖核酸酶抑制因子1抗體
xy-2966R    RBPJKNotch轉(zhuǎn)錄調(diào)控蛋白RBPJK抗體