沉默調(diào)節(jié)蛋白5抗體

英文名稱 SIRT5
中文名稱 沉默調(diào)節(jié)蛋白5抗體
別    名 NAD dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin 5; NAD-dependent deacetylase sirtuin-5; Silent mating type information regulation 2 S.cerevisiae homolog 5; Sir2 like 5; Sir2-like 5; SIR2-like protein 5; SIR2L5; Sirt5; SIRT5_HUMAN; Sirtuin type 5.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  心血管  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from hu SIRT5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the omeric, rDNA (ribosomal RNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT5 (NAD-dependent deacetylase sirtuin-5), also known as SIR2L5, is a 310 amino acid member of the class III sirtuins. Localized to mitochrondria and expressed throughout the body, SIRT5 is an NAD-dependent deacetylase that may link metabolic aging processes in humans. SIRT5 contains one deacetylase-sirtuin-type domain and can be deactivated by suramin, a drug that blocks the binding of various growth factors. Two isoforms of SIRT5 exist due to alternative splicing events.

Subcellular Location:
Mitochondrion matrix. Mitochondrion intermembrane space.xy-11149R    PCDHGA8原鈣粘蛋白γA8抗體
xy-11150R    PCDHGA9原鈣粘蛋白γA9抗體
xy-11151R    PCDHGA11原鈣粘蛋白γA11抗體
xy-11152R    PCDHGA12原鈣粘蛋白γA12抗體
xy-11153R    PCDHB12原鈣粘蛋白β12抗體
xy-11154R    PCDHB3原鈣粘蛋白β3抗體
xy-11155R    PCDHGB1原鈣粘蛋白γB1抗體
xy-11156R    PCDHGB2原鈣粘蛋白γB2抗體
xy-11157R    PCDHGB4原鈣粘蛋白γB4抗體
xy-11158R    PCDHGB6原鈣粘蛋白γB6抗體
xy-11159R    PCDHGC3原鈣粘蛋白γC3抗體
xy-11160R    PCDHGC4原鈣粘蛋白γC4抗體
xy-11327R    PTP zeta磷酸蛋白聚糖PTPRZ抗體
xy-11328R    PTPN5/STEP神經(jīng)特異蛋白酪氨酸磷酸酶N5抗體
xy-8688R    POD1足細(xì)胞表達(dá)蛋白/轉(zhuǎn)錄因子21抗體
xy-0183R    progesterone receptor孕激素受體抗體
xy-11354R    Piccolo神經(jīng)細(xì)胞突觸蛋白PCLO抗體
xy-6456R    PEN2 早老素γ分泌酶2抗體
xy-8337R    PANK1泛酸激酶1抗體
xy-8338R    PANK2泛酸激酶2抗體
xy-8339R    PANK3泛酸激酶3抗體
xy-8325R    PA26p53調(diào)控PA26核蛋白抗體
xy-8322R    Proteasome 19S S5A26S蛋白酶調(diào)節(jié)亞型S5a抗體
xy-8328R    PP4R3B絲氨酸/蘇氨酸蛋白磷酸酶3B抗體
xy-9547R    PGGT1A蛋白香葉烯基轉(zhuǎn)移酶1α抗體
xy-4895R    PIRH2泛素連接酶抗體
xy-9371R    PGBD3PGBD3蛋白抗體
xy-8340R    PANK4泛酸激酶4抗體
xy-6443R    PMCA1細(xì)胞膜鈣ATP酶1抗體