FBXL20抗體

抗原
F-Box and Leucine-Rich Repeat Protein 20 (FBXL20)
別名 fbl20, MGC81000, scrapper, Fbl2, Fbl20, 2610511F20Rik, 4632423N09Rik, AI849362, AL117906, C86145, Scr, mKIAA4147, Fbxl2, FBXL2
抗原表位
其他選擇 C-Term
N-Term(12),C-Term (8),Middle Region (2),AA 1-436 (1),AA 192-436 (1),AA 242-406 (1),Internal Region (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(41),Murine (27),Rat ((Rattus)) (27),Chicken (12),Bovine (12),Dog (Canine) (12)
宿主
其他選擇 Rabbit
Rabbit(40),Mouse (1)
克隆類型
多克隆
標記
其他選擇 非結(jié)合性
Alexa Fluor 350(1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Western Blotting (WB)(32),ELISA (19),Immunohistochemistry (IHC) (18),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6),Enzyme Immunoassay (EIA) (1),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

FBXL20抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

顯示 隱藏
免疫原 FBXL20 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human FBXL20.
亞型 IgG
特異性 This antibody detects FBXL20 at C-term.
交叉反應(yīng) （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affinity chromatography

目標詳細情況

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目標詳細情況

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別名 FBXL20
背景 Members of the F-box protein family, such as Scrapper, are characterized by an approximay 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.Synonyms: F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like, F-box/LRR-repeat protein 20, FBL2
基因ID 84961
NCBI Accession NP_116264
UniProt Q96IG2
研究領(lǐng)域 Neurology, Proteolysis / Ubiquitin

使用細節(jié)

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使用細節(jié)

顯示 隱藏
應(yīng)用備注 ELISA. Western blot: 0.5 - 1?μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

顯示 隱藏
緩沖液 PBS containing 0.02?% sodium azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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