PSENEN抗體

抗原
Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN)
別名 CG33198, DmelCG33198, Pen-2, anon-AE003800.1, dPen-2, T5E8.110, T5E8_110, Psenen, ACYPI006208, MSTP064, PEN-2, PEN2, 1700023M09Rik, RGD1312037
抗原表位
其他選擇 C-Term
N-Term(14),C-Term (11),AA 1-101 (2),AA 1-50 (1),AA 89-98 (1),Lys11 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(49),Murine (33),Rat ((Rattus)) (29),Bovine (14),Dog (Canine) (12),Pig (Porcine) (12),Hamster (2)
宿主
其他選擇 Rabbit
Rabbit(48),Mouse (3)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Alexa Fluor 350(1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(41),ELISA (20),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunofluorescence (IF) (8),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8),Immunohistochemistry (IHC) (7),Enzyme Immunoassay (EIA) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Immunohistochemistry (Paraformaldehyde) (IHC (pfa)) (1),Immunoprecipitation (IP) (1)
[Pubmed] 4 references available
規(guī)格 0.1 mg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

PSENEN抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 PEN2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2.
亞型 IgG
特異性 This antibody detects PEN2 at C-term.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affinity chromatography

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

顯示 隱藏
別名 PEN2
背景 PEN2, in addition to presenilin, nicastrin, and APH-1 forms the γ-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-α-converting enzyme (TACE) and the β-site cleavage enzyme (BACE) protease families, γ-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the α and γ cleavage site) or the toxic A?β amyloid peptide (from the β and γ cleavage site). It is thought that accumulation of the Aβ peptide is the precursor to Alzheimer's disease.Synonyms: Gamma-secretase subunit PEN-2, MDS033, PSENEN, Presenilin enhancer protein 2
基因ID 55851
NCBI Accession NP_758844
UniProt Q9NZ42
研究領(lǐng)域 Neurology, Alzheimer's Disease

使用細(xì)節(jié)

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使用細(xì)節(jié)

顯示 隱藏
應(yīng)用備注 ELISA. Western blot. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

顯示 隱藏
緩沖液 PBS containing 0.02?% sodium azide
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Avoid repeated freezing and thawing.
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