TOM1L1抗體

抗原
Target of Myb1 (Chicken)-Like 1 (TOM1L1)
別名 MGC52738, srcasm, TOM1L1, OK/KNS-CL.3, SRCASM, RGD1562626, Srcasm, 2310045L10Rik, C80573
適用
其他選擇 Human
Human(45),Murine (2)
宿主
其他選擇 Rabbit
Rabbit(35),Goat (6),Mouse (5)
克隆類型
多克隆
標記
其他選擇 Cy5.5
Biotin(2),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy7 (1),PE (1)
應用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Western Blotting (WB)(38),ELISA (18),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (9),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9),Immunohistochemistry (IHC) (7),Enzyme Immunoassay (EIA) (2),Immunoassay (IA) (2),Immunocytochemistry (ICC) (2),Immunofluorescence (IF) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1)
規格 100 μL
發貨至 中國 (更改)

TOM1L1抗體

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免疫原 KLH conjugated synthetic peptide derived from human TOM1L1
亞型 IgG
純化方法 purified by Protein A

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別名 TOM1L1
背景 Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.
研究領域 Signaling, Tyrosine Kinases

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應用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說明

Excitation / Emission wavelength: 675nm / 694nm

限制 For Research Use only

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狀態 Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲存條件 4 °C

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