BAMBI抗體

抗原
BMP and Activin Membrane-Bound Inhibitor Homolog (BAMBI)
別名 NMA, nma, BAMBI, Zfnma, bambi, cb998, fc44c12, id:ibd5020, wu:fc44c12, wu:fe01e03, 2610003H06Rik
抗原表位
其他選擇 AA 1-152
AA 1-152(7),AA 1-260 (1),AA 1-261 (1)
適用
其他選擇 Human
Human(26),Murine (15),Rat ((Rattus)) (15),Bovine (13),Dog (Canine) (13)
宿主
其他選擇 Rabbit
Rabbit(21),Mouse (5)
克隆類型
多克隆
標記
其他選擇 非結合性
PE(2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
zui低檢測濃度 0.00975 ng/well
應用范圍
其他選擇 ELISA
Flow Cytometry (FACS)(12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),ELISA (9),Western Blotting (WB) (8),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3)
[Pubmed] 1 reference available
規格 100 μg
發貨至 中國 (更改)

BAMBI抗體

產品細節

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產品細節

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亞型 IgG
特異性 Human BAMBI / NMA
產品特性 Produced in rabbits immunized with purified, recombinant Human BAMBI (rh BAMBI, NP_036474.1, Met 1-Ala 152). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 BAMBI
背景 BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF- beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.
NCBI Accession NP_036474.1
研究領域 Stem Cells

使用細節

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使用細節

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應用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human BAMBI. The detection limit for Human BAMBI is 0.00975 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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