Alk-Smase抗體

抗原
Alkaline Sphingomyelinase (Alk-Smase)
別名 ALK-SMase, E-NPP 7, NPP-7, Alk-SMase, Gm254
抗原表位
其他選擇 AA 1-439
AA 1-439(7),AA 290-320 (7),Internal Region (7),AA 1-458 (1),AA 22-421 (1),AA 234-458 (1),N-Term (1)
適用
其他選擇 Human
Human(37),Murine (17),Rat ((Rattus)) (13)
宿主
其他選擇 Rabbit
Rabbit(33),Mouse (5),Sheep (3)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(3),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
zui低檢測濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(25),ELISA (17),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Flow Cytometry (FACS) (7),Immunohistochemistry (IHC) (7),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5),Immunoprecipitation (IP) (3),Immunocytochemistry (ICC) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2),Immunoassay (IA) (1)
[Pubmed] 4 references available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

Alk-Smase抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
亞型 IgG
特異性 Human ENPP7 / NPP-7
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human ENPP7 / NPP-7 (rh ENPP7, NP_848638.2, Met 1-Ser 439). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 ENPP7
背景 Mouse Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the,nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.
NCBI Accession NP_848638.2
研究領(lǐng)域 Cancer, Cell Cycle

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1.0 μg/mL This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect ENPP7. The detection limit for Human ENPP7 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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