LDLR 抗體

抗原
Low Density Lipoprotein Receptor (LDLR)
別名 FH, FHC, LDLCQ2, Hlb301, LDLRA, LDLA
抗原表位
其他選擇 AA 1-790
AA 1-788(14),Extracellular Domain (10),AA 1-790 (9),AA 500-550 (8),Internal Region (8),AA 105-205 (4),AA 184-195 (4),AA 391-419 (2),AA 499-511 (2),C-Term (2),Center (2),AA 1-860 (1),AA 105-206 (1),AA 184-196 (1),AA 22-788 (1),AA 228-562 (1),AA 29-205 (1),AA 398-427 (1),AA 810-860 (1),AA 850 (1),N-Term (1)
適用
其他選擇 Murine
Human(95),Murine (40),Bovine (28),Rat ((Rattus)) (20),Dog (Canine) (12),Guinea Pig (12),Pig (Porcine) (12),Monkey (6),Hamster (1),Rabbit (1)
宿主
其他選擇 Rabbit
Rabbit(79),Mouse (27),Chicken (9),Goat (2)
克隆類型 (克隆位點(diǎn))
單克隆 (32)
標(biāo)記
其他選擇 FITC
Biotin(13),PE (6),FITC (5),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),DyLight 488 (1),DyLight 550 (1),DyLight 650 (1)
應(yīng)用范圍
其他選擇 Flow Cytometry (FACS)
Western Blotting (WB)(74),ELISA (46),Flow Cytometry (FACS) (42),Immunofluorescence (IF) (11),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (IHC) (10),Immunocytochemistry (ICC) (9),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9),Immunohistochemistry (Frozen Sections) (IHC (fro)) (7),Immunoprecipitation (IP) (7),Enzyme Immunoassay (EIA) (3),Functional Studies (Func) (2),Immunoassay (IA) (1),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1),Indirect Immunofluorescence Assay (IFA) (1)
規(guī)格 50 tests
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LDLR 抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 Recombinant Mouse LDLR / LDL Receptor protein
克隆位點(diǎn) 32
亞型 IgG
特異性 Mouse LDLR / LDL Receptor
產(chǎn)品特性 This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LDLR / LDL Receptor (rM LDLR / LDL Receptor, NP_034830.2, Met 1-Arg 790) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

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別名 LDLR
背景 Low-density lipoprotein (LDL) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues, and enables fats and cholesterol to move within the water-based solution of the blood stream. The Low-Density Lipoprotein Receptor (LDLR) is the prototype member of the LDLR family of scavenger receptors which is involved in receptor-mediated endocytosis of specific ligands. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). After taken into the cell ending up in lysosomes, LDL is degraded and the cholesterol is made available for repression of microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. As a mosaic protein, the extracellular region of LDLR consists of seven N-terminal complement-like cysteinerich repeats followed by three EGF like repeats with a β-propeller YWTD containing motif, and a membrane proximal Ser/Thr rich region. Furthermore, it is reported that in case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat (HIV-1 transactivator) into neurons, mediating its internalization in uninfected cells. Mutations in LDLR gene cause the autosomal dominant disorder, familial hypercholesterolemia.
NCBI Accession NP_034830.2

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應(yīng)用備注 Concentration: 10 μl/Test, 0.1 mg/ml
限制 For Research Use only

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狀態(tài) Liquid
緩沖液 Aqueous solution containing 0.5% BSA and 0.09% sodium azide
儲存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody is stable for 12 months from date of receipt when stored at 2 °C - 8 °C.
有效期 12 months

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