英文名稱 beta endorphin
中文名稱 β-內啡肽/β endorphin抗體
別    名 β-Endorphin; beta endorphin; βendorphin; beta endorfin; Beta endorphin; Corticotropin lipotropin; POMC; Proopiomelanocortin; COLI_HUMAN.
 β-內啡肽/β endorphin抗體   
說 明 書 0.1ml  0.2ml  
研究領域 免疫學  神經生物學  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Cow, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 4.5kDa
細胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human beta endorphin (237-267aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
 β-內啡肽/β endorphin抗體產品介紹 background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Location:
Secreted.

Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.

Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.

DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.

Similarity:
Belongs to the POMC family.

Gene ID:
5443

Database links:

Entrez Gene: 5443 Human

Entrez Gene: 24664 Rat

Omim: 176830 Human

SwissProt: P01189 Human

SwissProt: P01194 Rat

Unigene: 1897 Human β-內啡肽/β endorphin抗體xy-12514R ARFRP1ADP核糖基化因子相關蛋白1
xy-12515R Argininosuccinate Lyase琥珀酸裂解酶抗體
xy-12516R Arginyl tRNA synthetase精氨酰tRNA合成酶抗體
xy-12517R Argonaute 3真核翻譯起始因子2C3抗體
xy-12518R Argonaute 4真核翻譯起始因子2C4抗體
xy-12519R ARHGAP15Rho GTP酶激活蛋白15抗體
xy-12520R ARID1B抑癌基因結合蛋白ARID1B抗體
xy-12521R ARIH2E3連接酶蛋白ARIH2抗體
xy-12522R ARFL1ADP核糖基化樣因子1抗體
xy-12523R ARL4ADP核糖基化因子樣蛋白4抗體
xy-12524R ARP2肌動蛋白相關蛋白2/3抗體
xy-12527R ARPC2肌動蛋白相關蛋白2/3亞型2抗體
xy-12528R ARPC4肌動蛋白相關蛋白2/3亞型4抗體
xy-12530R ARSI芳香基硫酸酯酶家族蛋白1抗體
xy-12531R ART1腫瘤抑制相關蛋白PHEMX抗體
xy-12532R ARVCF精神分裂癥與犰狳重復基因抗體
xy-10162R ALDH1乙醛脫氫酶1型抗體
xy-12954R phospho-Acetyl Coenzyme A Carboxylase alpha (Ser80)磷酸化乙酰輔酶A羧化酶抗體
xy-12955R phospho-Acetyl Coenzyme A Carboxylase alpha (Ser1263)磷酸化乙酰輔酶A羧化酶抗體
xy-12956R phospho-ABCA1 (Ser2054)磷酸化腺苷三磷酸結合盒轉運體A1抗體
xy-12957R phospho-Aconitase 1 (Ser138)磷酸化鐵調節蛋白1抗體
xy-12958R phospho-Aconitase 1 (Ser711)磷酸化鐵調節蛋白1抗體
xy-12952R phospho-Acetyl Coenzyme A Carboxylase beta (Ser220)磷酸化乙酰輔酶A羧化酶抗體
xy-8997R Annexin VI膜粘連蛋白6抗體
xy-9401R ANKRD42錨蛋白重復結構域蛋白42抗體
xy-7738R Anillin胞環蛋白肌動蛋白結合蛋白抗體
xy-7697R Adenovirus 5 E1A binding protein腺病毒5結合蛋白BS69抗體(骨形態發生蛋白受體相關分子1)
xy-2314R APOA1載脂蛋白A1抗體