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南京科佰生物科技有限公司
主營產品： atcc代理,ATCC細胞系,ATCC細胞株,ATCC細胞庫購買 |
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南京科佰生物科技有限公司
主營產品： atcc代理,ATCC細胞系,ATCC細胞株,ATCC細胞庫購買 |
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| 參考價 | ￥ 900 |
| 訂貨量 | 1件 |
更新時間：2022-11-25 15:01:07瀏覽次數：530
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CBP10236 | |
| Format | Genomic DNA |
| Description | BRAF G469R is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469R demonstrates intermediate BRAF kinase activity (PMID: 28783719) and results in constitutive ERK activation in cell culture (PMID: 24920063), and in one of two cell lines leads to increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and is therefore predicted to confer a gain of function to the Braf protein. |
| Technical Data | |
| DNA Change | c.1405G>A |
| AA Change | p.G469R |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Transcript | ENST00000288602 |
| Cosmic ID | COSM457 |
| Chr position(GRCh37) | chr7:140481403 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
