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南京科佰生物科技有限公司

主營產品： atcc代理,ATCC細胞系,ATCC細胞株,ATCC細胞庫購買

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南京科佰生物科技有限公司

CBP73302BCR-ABL1 E459K/BaF3

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更新時間：2022-04-28 11:55:53瀏覽次數：2799

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【簡單介紹】

BCR-ABL1 [E459K]/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO；ABL1 是一種酪氨酸激酶，在正常細胞中，它在細胞分化和細胞周期調節中發揮作用。 BCR-ABL1 融合基因產生一種組成型活性酪氨酸激酶，導致不受控制的增殖。

【詳細說明】

CBP73302
I. Introduction
Cell Line Name：	BCR-ABL1 [E459K]/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes. ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation.

III. Representative Data
1.WB of BCR-ABL1 [E459K]/BaF3
2.Sanger of BCR-ABL1 [E459K]/BaF3 Figure 2. BCR-ABL1 [E459K]/BaF3 E549K Figure 3. BCR-ABL1 [E459K]/BaF3 Fusion
3. Anti-proliferation assay Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 E459K Cells (C8).