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CP-466722,ATM/ATR 抑制劑,ATM/ATR inhibitors

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更新時間:2024-09-10 20:27:23瀏覽次數:1308次

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CP-466722,ATM/ATR 抑制劑,ATM/ATR inhibitors
別名:CP466722
分子量 (MW):349.35
化學式:C17H15N7O2
溶解度: DMSO 0.28mg/mL Water <1mg/mL Ethanol <1mg/mL
穩定性:at -20℃ 2 years
CAS號:1080622-86-1

上海義森生物科技有限公司提供:CP-466722,ATM/ATR 抑制劑,ATM/ATR inhibitors

 

 

技術數據:

分子量(MW): 349.35 CP-466722 Chemical Structure
化學式:

C17H15N7O2

溶解度: DMSO 0.28mg/mL   Water <1mg/mL   Ethanol <1mg/mL
純度: >99%
穩定性: at -20℃ 2 years
CAS號: 1080622-86-1

生物活性

 

CP-466722 is rapidly reversible potential ATM kinase inhibitor. CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and compley reversed by removing CP466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies. [1]

 

參考文獻

  • Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation Maura E. Charlton, Robert V. Stanton, et al. Cancer Res 2008;68:7466-7474

上海義森生物科技有限公司提供:CP-466722,ATM/ATR 抑制劑,ATM/ATR inhibitors

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