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      在3月，春暖花開的季節，讓我們熱烈恭賀中國農業大學的譚老師成功贏取了恒遠生物“SCI文獻獎學金"！譚老師之前訂購了恒遠生物高敏ELISA試劑盒，使用了我們的產品在《ADVANCED SCIENCE》雜志上發表了文獻——Designing Self-Assembling Chimeric Peptide Nanoparticles with High Stability for Combating Piglet Bacterial Infections，IF影響因子高達16.8分！恒遠生物在此也非常感謝譚老師對我們信任與支持，希望通過我們的不懈努力能為科研事業做出更大的貢獻！讓我們再次祝賀譚老師！

一、恒遠產品文獻分享：

【文獻標題】Designing Self-Assembling Chimeric Peptide Nanoparticles with High Stability for Combating Piglet Bacterial Infections

【作者】Peng Tan, Qi Tang, Shenrui Xu,et.al

【作者單位】中國農業大學（China Agricultural University）

【文獻中引用產品】

小鼠白介素6(IL-6)ELISA試劑盒

小鼠白介素1β (IL-1β)ELISA試劑盒

小鼠腫瘤壞死因子α(TNF-α)ELISA試劑盒

【DOI】doi.org/10.1002/advs.202105955

【影響因子(IF)】16.8

【出版期刊】《ADVANCED SCIENCE》

【產品原文引用】

Blood was collected from the orbital vein of the mice, and using an enzyme-linked immunoassay to analyze cytokine levels in the serum. The inflammatory factor kit was purchased from Shanghai Hengyuan Biological Technology Co., Ltd.

Moreover, compared with the saline treatment group, the levels of pro-inflammatory factors TNF-α, interleukin-6 (IL-6), and interleukin-1 (IL-1) in the serum of mice in the peptide nanoparticle treatment group were significantly reduced (Figure 6j–l). These cytokines are key factors affecting the inflammatory response in acute sepsis. Considering the action mechanism of peptide nanoparticles, combining them with LPS to reduce the circulation of endotoxins in vivo may limit the immunogenic potential of mice.[41] These results indicate that peptide nanoparticles not only exert direct antibacterial effects but also have immunomodulatory properties. These effects complement each other and help prevent systemic bacterial infections. Hematoxylin and eosin (H&E) staining showed pathological changes in the tissues of infected mice, including hepatocyte damage, vacuoles around the glomerulus, and inflammatory cell infiltration (Figure 6i). After peptide nanoparticle treatment, tissue damage was largely prevented or restored

       

       這篇文獻非常值得研讀，其中的很多實驗方法和思路值得我們去學習，一篇文獻的誕生要費很多精力和心血，譚老師在做實驗的過程中也遇到了很多難題，我們的技術人員也盡力提供幫助，互相學習互相進步。小編想要把這篇文獻分享給大家，希望能夠對做科研的小伙伴們有一點點幫助，也希望大家積極的參與我們的“贏獎學金"活動，小編等著你們的投稿哦，下一個領獎學金的說不定就是你！