DermiGen DermiGen Modified Tension Bioreactor,3D皮膚牽張應(yīng)力加載培養(yǎng)分析儀(皮膚振蕩拉伸壓縮刺激生物反應(yīng)器)對(duì)處于的空氣—培養(yǎng)基界面的樣本施加靜態(tài)/振蕩拉伸和壓縮刺激。其應(yīng)用范圍包括細(xì)胞功能研究、組織工程構(gòu)建物的生長和發(fā)育以及藥物測(cè)試和再生療法。DermiGen系統(tǒng)也可以實(shí)現(xiàn)用戶自定義的應(yīng)力/應(yīng)變波形。

DermiGen生物反應(yīng)器系統(tǒng)包括拉伸/壓縮機(jī)械刺激。伺服電機(jī)配置整體干軸承，刺激器重量輕，結(jié)構(gòu)緊湊，耐腐蝕，并且兼容大多數(shù)標(biāo)準(zhǔn)的孵化器。刺激器同時(shí)控制負(fù)載和位移，其緊湊的尺寸允許4刺激器和反應(yīng)室單元適應(yīng)標(biāo)準(zhǔn)的孵化器架。刺激器規(guī)格：

*        尺寸：72mm x420mm x 115mm  （ H x L x W ）

*        峰值力：44N

*        持續(xù)力：20N

*       重量：2.2kg

D70-1 DermiGen 生物反應(yīng)器系統(tǒng)

D70-1 DermiGen系統(tǒng)被配置為一個(gè)單一的樣品生物反應(yīng)器系統(tǒng)，通過用戶定義的刺激協(xié)議，能夠支持廣泛的細(xì)胞和組織生長實(shí)驗(yàn)。此系統(tǒng)可以定制特殊的研究應(yīng)用。

·    樣品長度：45 - 70 mm

·    樣品厚度：0.1 - 2 mm

·    樣品寬度：20 mm

D70-4 DermiGen 生物反應(yīng)器系統(tǒng)

D70-4已被設(shè)計(jì)成一個(gè)多刺激的生物反應(yīng)器系統(tǒng)。GrowthWorks軟件/控制器操作4個(gè)獨(dú)立的D70-1刺激器，以增加樣品的測(cè)試能力。如同D70-1一樣，此系統(tǒng)可以定制特殊的研究應(yīng)用。

反應(yīng)室

由生物惰性、高壓滅菌的材料制成，DermiGen生物反應(yīng)器室提供靜態(tài)和振蕩拉伸刺激。該反應(yīng)室的*設(shè)計(jì)提供了一個(gè)空氣/介質(zhì)界面，以促進(jìn)細(xì)胞共同培養(yǎng)和皮膚類樣品的開發(fā)。反應(yīng)室協(xié)助介質(zhì)沿構(gòu)建體底部灌注/流動(dòng)，同時(shí)阻止介質(zhì)溢到上部。一種*的密封件提供了一個(gè)機(jī)械饋道（真空密封通路）與反應(yīng)室，同時(shí)以zui小的阻力在無菌環(huán)境中進(jìn)行軸向運(yùn)動(dòng)。用帶有柔軟襯里的機(jī)械夾具保證樣品的安全定位

ProductsDermiGen: Tension Bioreactor with Air/Media Interface

The DermiGen bioreactors impart static and oscillatory stimulation to a "skin like" sample in a unique air-to-nutrient media interface. Applications include investigating cell function and stimulating the growth and development of engineered tissues.  The device can also be used as a "test bed" for pharmaceutical and regenerative therapies. The DermiGen can apply either stress or strain using operator defined wave forms.

D70-1 DermiGen

The D70-1 system is configured as a single sample bioreactor system that is able to support a wide range of of cell and tissue growth experiments via user defined stimulating protocols.  The chamber's unique design provides an air/media interface to facilitate cell co-culture and the development of skin like products. The chamber provides media perfusion/flow along the underside of the construct while preventing it from migrating onto the topside.  Mechanical clamp grips with soft linings provide secure positioning of the sample. This chamber can accommodate a single sample with a maximum length of 45-70mm, 20mm width  and 0.1 to 2mm thickness. The instrument may be customized to specific research applications.

D70-4 DermiGen

The D70-4 DermiGenhas been designed as a multi-stimulator bioreactor system. The GrowthWorks Software/Controller operates four (4) independent D70-1 Stimulators to provide increased sample capabilities. As with the D70-1, these instruments may be customized for specific research applications.

GrowthWorks® Software & Control:

The GrowthWorks Software and Control platform includes advanced capabilities, such as multiple waveform control, data acquisition and multi-motor operation. The intuitive software runs on a Windows® laptop computer and features a simple user interface. User defined stimulation profiles are controlled by the software and are readily monitored using graphical displays. Integrated data acquisition routines capture and record data at user prescribed intervals. The GrowthWorks Software is configurable for running four stimulators while simultaneously monitoring up to 16 transducers, allowing the researcher maximum flexibility.

The GrowthWorks Control Hardware features an embedded In CPU, integrated data acquisition and integrated motor drives. Communications between the laptop and control hardware is transmitted over a standard network cable. Primary advantages of the BISS Laptop/Controller approach are reduced physical size and easy upgradability. As future Windows versions or higher performance Laptops become available, either can be replaced without any software or controller changes. This ensures the GrowthWorks control system will be an integral part of your research for many years to come.

GrowthApps Stiffness Measurement & Adaptive Control:

The GrowthApps modules provide added capability to GrowthWorks. The addition of the Stiffness Measurement & Adaptive Control Application enables the system to make real-time measurements of the sample stiffness during culture. Described in U.S. Patent 7,410,792 B2 Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products., the Application measures the mechanical response of the tissue construct as it is being stimulated and conditioned. The stiffness measurements can be used as guidelines for bench marking progress during culturing or for modifying the stimulation profile. Based upon the measured response, the bioreactor system is then capable of altering the stimulation profile. This technology enables researchers to automatically culture the skin from initial seeding to an implantation-ready state with minimal operator intervention.