公司擁有ABGENT、B-bridge、IBL-America、R&D、CST、MBL、SAB、KPL、Santa、Abnova、LifeSpan等  顆粒酶A抗體品牌全年代理權(quán)，價格行業(yè)優(yōu)勢明顯。
英文名稱 Anti-GZMA/Granzyme A
中文名稱 顆粒酶A抗體
 別 名 CTL tryptase; CTLA3; Cytolytic t cell and natural killer cell specific trypsin like serine protease; Cytotoxic T lymphocyte associated serine esterase 3; Cytotoxic T lymphocyte proteinase 1; Cytotoxic T-lymphocyte proteinase 1; Fragmentin 1; Fragmentin-1; GRAA_HUMAN; Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3; Granzyme A （Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease）; Granzyme A （granzyme 1, cytotoxic T lymphocyte associated serine esterase 3）; Granzyme A; Granzyme A precursor; Granzyme-1; GZMA; H factor; Hanukah factor serine protease; Hanukkah factor; HF; HFSP; TSP1.
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse
產(chǎn)品類型 一抗
研究領(lǐng)域 細(xì)胞生物 免疫學(xué) 細(xì)胞凋亡 t-淋巴細(xì)胞
46855IKB Beta （Inhibitor of KB） KB抑制蛋白β（多肽） 0.5mg
46856IKB Alpha （Inhibitor of KB Alpha） KB抑制蛋白α抗原 0.5mg
46857IL-12（Interleukin-12） 白介素12抗原（白細(xì)胞介素-12） 0.5mg
46858IL-12（Interleukin-12）human peptide 白介素12抗原（人） 0.5mg
46859IL-12R Beta2/IL12RB2 peptide 白細(xì)胞介素-12受體β2抗原 0.5mg
46860IL-13（Interleukin-13） 白介素13抗原 0.5mg
46861IL-14/Taxilin alpha 白介素14抗原 0.5mg
46862IL-15（Interleukin-15） 白細(xì)胞介素-15抗原 0.5mg
46863IL-16（Interleukin-16） 白介素16抗原 0.5mg
46864IL-16/LCF（interleukin-16）（Lymphocyte Chemotactic Factor） 白細(xì)胞介素-16抗原 0.5mg
46865IL-17（Interleukin-17） 白介素-17抗原 0.5mg
46866IL-17（Interleukin-17）human 白介素-17抗原（人） 0.5mg
46867IL-18/IGIF（Interleukin-18） 白細(xì)胞介素-18/干擾素γ誘導(dǎo)因子 0.5mg
46868IL-23R（Interleukin-23 receptor） 白介素-23受體抗原 0.5mg
46869IL-1 Alpha （Interleukin-1 Alpha ） 白介素1α抗原 0.5mg
46870IL-2 （Interleukin-2）Mouse、Ret 白介素2抗原（大、小鼠） 0.5mg
46871IL-2 （Interleukin-2）Human IL-2抗原（人） 0.5mg
46872IL-23（Interleukin-23） 白介素-23抗原 0.5mg
46873IL-4（Interleukin-4） 白介素4抗原 0.5mg
46874IL-4（Interleukin-4）human peptide 白介素4抗原 0.5mg
46875IL-5 peptide 白細(xì)胞介素5抗原 0.5mg
46876IL-6 （Interleukin-6） Human 白介素6 0.5mg
46877IL-7（Interleukin-7） 白介素7抗原 0.5mg
46878IL-6R Alpha （IL6R-alpha） 白細(xì)胞介素6受體α抗原 0.5mg
46879gp130/IL-6R 白介素-6受體抗原 0.5mg
46880IL-7Ra/CD127 peptide 白細(xì)胞介素-7受體a抗原 0.5mg
46881ING1/p33（inhibitor of growth gene 1） 生長抑制因子基因1抗原 0.5mg
46882Inhibin Alpha 抑制素α抗原 0.5mg
46883Inhibin beta A peptide 抑制素beta A抗原 0.5mg
46884Inhibin beta B 抑制素βB抗原 0.5mg
46885Integrin Alpha3 整合素α3抗原 0.5mg
46886Integrin Beta5 整合素β5抗原 0.5ml
46887Integrin alpha 1 整合素α1抗原 0.5mg
46888Integrin Alpha4 Beta7/LPAM-1 （Lymphocyte Peyer’s patch Adhesion Molecule 1/Integrin alpha4,beta7） 整合素α4β7抗原 0.5mg
46889Integrin AlphaE2/CD103 整合素αE2抗原 0.2ml
46890ENPP3/CD203c（ectonucleotide pyrophosphatase/phosphodiesterase 3） ENPP3抗原 0.5mg
46891IQGAP1 支架蛋白抗原 0.5mg
46892IRF-1（Interferon regulatory factor-1） 干擾素調(diào)節(jié)因子抗原 0.5mg
46893IRAK 2 白介素-1受體相關(guān)激酶2 0.5mg
46894IL-1RA （Interleukin-1 receptor antagonist）peptide 白介素-1受體拮抗劑抗原 0.5mg
 46895Integrin a7（integrin alpha 7） 整合素α7抗原 0.5mg
蛋白分子量 predicted molecular weight: 26kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human GZMA C-terminus
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 產(chǎn)品介紹 Granzyme A is the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme A is unique among granzymes in that it is a disulfide linked homodimer. Granzyme B is thought to be a rapidly acting apoptotic enzyme, while Granzyme A is thought to be slow acting. Granzyme A is a 28 kD protein. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.
Function : This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
Subunit : Homodimer; disulfide-linked. Interacts with APEX1.
Subcellular Location : Isoform alpha: Secreted. Cytoplasmic granule.
Similarity : Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
Database links : UniProtKB/Swiss-Prot: P12544.2
GzmA是存在于細(xì)胞毒性T淋巴細(xì)胞（CTL）和自然殺傷細(xì)胞（NK細(xì)胞）的細(xì)胞毒顆粒中含量zui多的一種絲氨酸蛋白酶。