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英文名稱 Anti-GGH/Glutamyl hydrolase gamma
中文名稱 γ-谷氨酰水解酶抗體
γ-谷氨酰水解酶抗體 別 名 Conjugase; EC 3.4.19.9; folylpolygammaglutamyl hydrolase; gamma glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; Gamma-glutamyl hydrolase; GGH; GGH_HUMAN; gH.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Rabbit
產品類型 一抗
研究領域 腫瘤 細胞生物 信號轉導 干細胞 新陳代謝
46706sFRP-4（Secreted frizzled-related protein 4; Frizzled protein, human endometrium） 抗子宮內膜抗原 0.5mg
46707Endostatin 內皮抑素/內皮他丁抗原 0.5mg
46708EpCAM（Epithelial cell adhesion molecule） 上皮細胞粘附分子/表皮細胞粘附分子（多肽） 0.5mg
46709EpCAM/CD326（Epithelial cell adhesion molecule） 上皮細胞粘附分子/表皮細胞粘附分子抗原 0.5mg
46710E.coli O6 （Escherichia coli O6） E.coli O6大腸桿菌菌體蛋白 0.5mg
46711EPEC/E.coli（enteropathogenic E．coli，EPEC） 普通大腸埃希菌菌體蛋白（非致病性） 1mg
46712EphA1 R（Ephrin A1 Receptor） EphA1-R受體抗原 0.5mg
46713EPOR peptide 紅細胞生成素受體抗原 0.5mg
46714phospho-ERK1/MAPK-1/2（pThr183 + pTyr185） 磷酸化絲裂原活化蛋白激酶1/2抗原 0.5mg
46715ERK（Extracellular signal-regulated kinase） 絲裂原活化蛋白激酶抗原 0.5mg
46716MAPK1/ERK3 （Mitogen-activated protein kinase 3; P44MAPK） 絲裂原活化蛋白激酶3抗原 0.5mg
46717MAPK4（Mitogen-activated protein kinase 4） 絲裂原活化蛋白激酶4抗原 0.5mg
46718ER- Alpha（phospho-Ser167）peptide 人磷酸化雌激素受體α多肽抗原 0.5mg
46719ER- Alpha（phospho-Tyr537）peptide 磷酸化雌激素受體α抗原 0.5mg
46720ER- Alpha /ER alpha peptide 雌激素受體α抗原 0.5mg
46721ER- Alpha/ER alpha peptide 雌激素受體α抗原 0.5mg
46722ER- Beta （Estrogen receptor-beta） peptide 雌激素受體β抗原 0.5mg
46723ets1/E26 （E-twenty six 1） Ets轉錄因子家族ets1抗原 0.5mg
46724EV71（Human enterovirus 71）VP1 腸道病毒71型/手足口病病毒抗原 0.5mg
46725EV71（Human enterovirus 71）VP1（CT） 腸道病毒71型/手足口病病毒抗原（C端） 0.5mg
46726ATEXPA10 peptide 植物擴張蛋白ATEXPA10（擬南芥）抗原 0.5mg
46727Ezrin/Radixin 埃茲蛋白（多肽） 0.5mg
46728F1 operon positive regulatory protein（NT） 鼠疫耶爾森氏菌F1莢膜蛋白（N端多肽） 0.5mg
46729F1 operon positive regulatory protein（CT） 鼠疫耶爾森氏菌F1莢膜蛋白（C端多肽） 0.5mg
46730FABP（brain） （Fatty acid-binding protein brain） 腦型脂肪酸結合蛋白抗原 0.5mg
46731FADD （Fas-associated protein with death domain） Fas死亡結構域相關蛋白抗原 0.5mg
γ-谷氨酰水解酶抗體46732FAK（Focaladhesin kinase） 粘著斑激酶抗原 0.5mg
蛋白分子量 predicted molecular weight: 34kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human GGH/Glutamyl hydrolase gamma
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
γ-谷氨酰水解酶抗體產品介紹 GGH is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers. The gene encoding GGH maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
Function : Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate （folic acid） and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Subunit : Homodimer.
Subcellular Location : Secreted; extracellular space. Lysosome. Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity : Belongs to the peptidase C26 family.
Contains 1 gamma-glutamyl hydrolase domain.
Database links : UniProtKB/Swiss-Prot: Q92820.2