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Borussertib

CAS No. : 1800070-77-2

產品活性：Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC₅₀ of 0.8 nM and a K_i of 2.2 nM for Akt^wt.

研究領域：PI3K/Akt/mTOR

作用靶點：Akt

In Vitro: Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. The EC₅₀ values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively.

相關產品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Glucose Metabolism Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  LM22B-10  |  Insulin Detemir  |  (rac)-AG-205  |  Multi-kinase-IN-2  |  Akt/SKG Substrate Peptide  |  AS1949490  |  1,3-Dicaffeoylquinic acid  |  Threo-Chloramphenicol-d₆  |  NSC45586  |  APN/AKT-IN-1  |  MS5033  |  Sophocarpine monohydrate  |  MS143  |  Deferoxamine  |  Chaetominine  |  Hu7691 free base  |  AKT-IN-3  |  8-Aminoadenosine  |  Nrf2/HO-1 activator 2  |  AT13148  |  Pachymic acid  |  Polygalasaponin F  |  Akt1&PKA-IN-1  |  Triciribine  |  PI3K-IN-29  |  Oxaprozin  |  CCT128930  |  YS-49  |  (?)-Myrtenal

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