Bax mouse mAb
抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動(dòng)物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的。抗體以一個(gè)或者多個(gè)Y字形單體存在，每個(gè)Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈?zhǔn)歉鶕?jù)它們的分子量大小來(lái)命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個(gè)抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個(gè)抗體的重鏈則決定了它的類(lèi)或型。
產(chǎn)品詳情
This antibody detects endogenous levels of Bax and does not cross-react with related proteins.
免疫原詳細(xì)信息
Purified recombinant human Bax protein fragments expressed in E.coli
相關(guān)試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
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備注：圖片僅供參考。僅供科研，不可用于臨床。
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