CD200抗體

抗原
CD200 Molecule (CD200)
別名 CD200, MOX2, DKFZp459C0716, ox2g, Mox2, OX2, MOX1, MRC, OX-2, Cspmo2, MRCOX2
抗原表位
其他選擇 AA 1-232
AA 1-232(13),C-Term (13),AA 182-211 (7),AA 31-232 (3),AA 183-211 (2),AA 1-269 (1),AA 34-124 (1),Internal Region (1)
適用
其他選擇 Human
Murine(78),Human (76),Rat ((Rattus)) (68),Bovine (2),Dog (Canine) (2),Guinea Pig (2),Pig (Porcine) (2),Rabbit (2),Horse (Equine) (1)
宿主
其他選擇 Rabbit
Mouse(98),Rat (54),Rabbit (39),Goat (3)
克隆類型
多克隆
標記
其他選擇 非結合性
FITC(36),PE (33),Biotin (26),APC (3),Alexa Fluor 647 (3),HRP (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
zui低檢測濃度 0.00245 ng/well
應用范圍
其他選擇 ELISA
Flow Cytometry (FACS)(156),Immunohistochemistry (Frozen Sections) (IHC (fro)) (36),ELISA (31),Western Blotting (WB) (26),Immunohistochemistry (IHC) (17),Immunoprecipitation (IP) (17),Immunohistochemistry (Acetone-fixed) (IHC (af)) (11),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7),Enzyme Immunoassay (EIA) (3),Functional Studies (Func) (2),Immunoassay (IA) (1),Immunocytochemistry (ICC) (1),Neutralization (Neut) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

CD200抗體

產品細節(jié)

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產品細節(jié)

顯示 隱藏
亞型 IgG
特異性 Human CD200 / OX-2
產品特性 Produced in rabbits immunized with purified, recombinant Human CD200 (rh CD200, NP_005935.4, Met 1-Gly 232). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 CD200
背景 CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
NCBI Accession NP_005935.4
研究領域 CD Antigens, Surface Receptors of Immune Cells

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA ELISA: 0.5-1.0 μg/mL This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CD200. The detection limit for Human CD200 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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